Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807223 | 0.88 | IRAK4 (0.46) | PIK3CDPIK3R1IRAK4KITJAK2 | |
| SCHEMBL807212 | 0.87 | PIK3CD (0.46) | PIK3CDPIK3R1KITJAK2LRRK2 | |
| SCHEMBL807280 | 0.86 | PIK3CD (0.50) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB | |
| SCHEMBL789847 | 0.81 | JAK2 (0.46) | PIK3CDJAK2PIK3CAKCNH2MTOR | |
| SCHEMBL789385 | 0.79 | BMPR1B (0.45) | PIK3CDPIK3R1JAK2LRRK2PIK3CA | |
| SCHEMBL10277093 | 0.79 | KDM4E (0.43) | PIK3CDIRAK4PIK3CAPIK3CGPIK3CB | |
| SCHEMBL806763 | 0.77 | KIT (0.49) | PIK3CDPIK3R1IRAK4KITLRRK2 | |
| SCHEMBL789702 | 0.72 | PIK3CG (0.52) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB | |
| SCHEMBL789701 | 0.72 | PIK3CG (0.73) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB | |
| SCHEMBL807275 | 0.71 | PIK3CG (0.63) | PIK3CDPIK3R1PIK3CAPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |