Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | ATR | Q13535 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ERN1 | O75460 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789847 | 0.85 | JAK2 (0.46) | JAK2GRM2ATRKCNH2HPGD | |
| SCHEMBL790716 | 0.84 | MAPT (0.43) | HPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL807223 | 0.80 | IRAK4 (0.46) | JAK2ATRKCNH2HPGDPIK3CA | |
| SCHEMBL10277681 | 0.74 | LRRK2 (0.47) | JAK2ATRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL789402 | 0.74 | CYP1A2 (0.41) | HPGDKDM4EALDH1A1CYP1A2 | |
| SCHEMBL109082 | 0.71 | PHGDH (0.69) | HPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL807334 | 0.69 | KCNH2 (0.54) | JAK2GRM2ATRKCNH2HPGD | |
| SCHEMBL4355847 | 0.68 | JAK2 (0.56) | JAK2GRM2KCNH2HPGDERN1 | |
| SCHEMBL24547937 | 0.68 | HPGD (0.46) | JAK2GRM2HPGDKDM4EALDH1A1 | |
| SCHEMBL8172365 | 0.67 | EPHX2 (0.71) | HPGDERN1HDAC4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |