Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.44 |
| ▸ | MMP13 | P45452 | 12/20 | 0.44 |
| ▸ | MMP1 | P03956 | 11/20 | 0.44 |
| ▸ | MMP9 | P14780 | 8/20 | 0.44 |
| ▸ | MMP3 | P08254 | 7/20 | 0.44 |
| ▸ | MMP14 | P50281 | 5/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.41 |
| ▸ | MMP7 | P09237 | 3/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | MMP10 | P09238 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991333 | 0.93 | MMP2 (0.40) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL7001935 | 0.79 | MMP1 (0.46) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL7310714 | 0.73 | MMP1 (0.63) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL25832 | 0.72 | MMP1 (0.57) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL25908 | 0.72 | MMP1 (0.56) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL6995105 | 0.72 | MMP1 (0.57) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL7002033 | 0.71 | MMP1 (0.55) | MMP2MMP13MMP1MMP9MMP3 | |
| Hydroxyamine SCHEMBL5914637 | 0.68 | MMP1 (0.74) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL6787427 | 0.68 | MMP1 (0.81) | MMP2MMP13MMP1MMP9MMP3 | |
| SCHEMBL9938067 | 0.67 | MMP1 (0.77) | MMP2MMP13MMP1MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110964-A | FOR TREATING ARTHRITIS, INFLAMMATORY BOWEL DISEASE, CROHN'S DISEASE, EMPHYSEMA, ACUTE RESPIRATORY DISTRESS SYNDROME, ASTHMA CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ALZHEIMER'S DISEASE, ORGAN TRANSPLANT TOXICITY, CACHEXIA, CANCER | PFIZER INC. (US) | 2000-08-29 | — | — | US | claimed |