Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16328294 | 0.79 | TRPV4 (0.36) | TRPV4 | |
| SCHEMBL10196090 | 0.76 | TRPV4 (0.32) | TRPV4 | |
| SCHEMBL229945 | 0.73 | TRPV4 (0.60) | TRPV4PIK3CAPI4KBPIK3CDPIK3CB | |
| SCHEMBL4149032 | 0.73 | TRPV4 (0.60) | TRPV4 | |
| SCHEMBL485933 | 0.73 | TRPV4 (1.00) | TRPV4PIK3CAPI4KBPIK3CDPIK3CB | |
| SCHEMBL2643090 | 0.71 | TRPV4 (0.64) | TRPV4PIK3CAPI4KBPIK3CDPIK3CB | |
| SCHEMBL114542 | 0.71 | TRPV4 (0.58) | TRPV4PIK3CAPI4KBPIK3CDPIK3CB | |
| SCHEMBL227613 | 0.71 | TRPV4 (0.58) | TRPV4PIK3CAPI4KBPIK3CDPIK3CB | |
| SCHEMBL3168829 | 0.71 | TRPV4 (0.58) | TRPV4PIK3CAPI4KBPIK3CDPIK3CB | |
| SCHEMBL130933 | 0.71 | TRPV4 (0.58) | TRPV4PIK3CAPI4KBPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017175068-A1 | THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS | MANKIND PHARMA LTD. (IN) | 2017-10-12 | — | — | WO | disclosed |
| CN-104684899-B | Substituted sulfonamide compounds | 霍夫曼-拉罗奇有限公司 | 2017-07-04 | — | — | CN | disclosed |
| WO-2017069226-A1 | NOVEL NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND | 田辺三菱製薬株式会社 | 2017-04-27 | — | — | WO | disclosed |
| EP-2814820-B1 | ANTI-MALARIAL AGENTS | UNIV CAPE TOWN (ZA) | 2016-07-20 | — | — | EP | disclosed |
| US-9193747-B2 | Organic electroluminescent device | UDC IRELAND LIMITED (IE) | 2015-11-24 | — | — | US | disclosed |
| WO-2015052264-A1 | SUBSTITUTED HETEROCYCLIC SULFONAMIDE COMPOUNDS USEFUL AS TRPA1 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-16 | — | — | WO | disclosed |
| WO-2013121387-A1 | ANTI -MALARIAL AGENTS | UNIVERSITY OF CAPE TOWN (ZA) | 2013-08-22 | — | — | WO | disclosed |
| EP-2548874-A2 | Substituted piperazines as CB1 antagonists | Intervet International B.V. (NL) | 2013-01-23 | — | — | EP | disclosed |
| US-20100171111-A1 | ORGANIC ELECTROLUMINESCENT DEVICE | FUJIFILM CORPORATION (JP) | 2010-07-08 | — | — | US | disclosed |
| WO-2009015897-A1 | NOVEL HETEROCYCLIC COMPOUNDS AS MGLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100171111-A1 | ORGANIC ELECTROLUMINESCENT DEVICE | NDUFS3, NDUFS2, NDUFS4 | TRPV4 988/4885PIK3CA 3017/4885PI4KB 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.