NDUFS2

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial · O75306 · NDUFS2 on Sugi Atlas →

3,243 patent compounds predicted against NDUFS2, 2,014 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Auraptene Auraptene (SCHEMBL2535029) 1.00 5/20
Auraptene Auraptene (SCHEMBL2535034) 1.00 5/20
SCHEMBL8491443 SCHEMBL8491443 0.56 4/20
SCHEMBL8489900 SCHEMBL8489900 0.52 4/20
SCHEMBL8489907 SCHEMBL8489907 0.52 4/20
SCHEMBL8489902 SCHEMBL8489902 0.51 4/20
SCHEMBL8489908 SCHEMBL8489908 0.51 4/20
SCHEMBL8491154 SCHEMBL8491154 0.51 4/20
SCHEMBL8491160 SCHEMBL8491160 0.51 4/20
SCHEMBL8491619 SCHEMBL8491619 0.50 4/20
SCHEMBL8491624 SCHEMBL8491624 0.50 4/20
SCHEMBL8491634 SCHEMBL8491634 0.50 4/20
7-Prenyloxycoumarin 7-Prenyloxycoumarin (SCHEMBL4898255) 0.79 3/20
SCHEMBL712741 SCHEMBL712741 0.57 3/20
Geiparvarin Geiparvarin (SCHEMBL2532495) 0.56 3/20
SCHEMBL6267768 SCHEMBL6267768 0.55 3/20
SCHEMBL1095981 SCHEMBL1095981 0.55 3/20
SCHEMBL4293165 SCHEMBL4293165 0.55 3/20
SCHEMBL8490928 SCHEMBL8490928 0.53 3/20
SCHEMBL8490937 SCHEMBL8490937 0.53 3/20

Clinical trials — most relevant to NDUFS2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease PHASE3COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome PHASE1/PHASE2COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease PHASE2COMPLETED
Parkinson's Disease Treatment With Coenzyme Q10 PHASE2COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Mitoquines in COPD nanUNKNOWN
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection nanCOMPLETED
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip nanCOMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
The Natural History of Mitochondrial Diseases nanRECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Cardiac Mitochondrial Function in Explanted Human Hearts nanUNKNOWN
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer) nanCOMPLETED
Assessment of Follicular Fluid Level of Coenzyme Q10 in Women Undergoing ICSI nanUNKNOWN
Mitochondria and Metabolic Syndrome in a Southern California Chinese Cohort nanCOMPLETED
Nicotinamide Riboside and Mitochondrial Biogenesis nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFS2 binder may also engage these)

ProteinNameSimilarity
Q0MQG5 1.000 Q0MQG5 →
Q641Y2 1.000 Q641Y2 →
P17694 1.000 P17694 →
Q0MQG3 1.000 Q0MQG3 →
P22142 1.000 P22142 →
Q91WD5 1.000 Q91WD5 →
Q0MQG4 1.000 Q0MQG4 →
A1V2L9 1.000 A1V2L9 →
A3N7M0 1.000 A3N7M0 →
Q1BV16 1.000 Q1BV16 →
Q1GTK0 1.000 Q1GTK0 →
B0SFT7 1.000 B0SFT7 →
Q0I6T6 1.000 Q0I6T6 →
A5VPY6 1.000 A5VPY6 →
B4RCM6 1.000 B4RCM6 →
B1YTQ4 1.000 B1YTQ4 →
Q0KCS7 1.000 Q0KCS7 →
P9WJH5 1.000 P9WJH5 →
P65570 1.000 P65570 →
Q0BDD3 1.000 Q0BDD3 →
Q5P1E7 1.000 Q5P1E7 →
Q0APY7 1.000 Q0APY7 →
Q57DU8 1.000 Q57DU8 →
Q2YNG0 1.000 Q2YNG0 →
Q3AVZ9 1.000 Q3AVZ9 →
A1SE30 1.000 A1SE30 →
A4TDA8 0.999 A4TDA8 →
Q47LE7 0.999 Q47LE7 →
Q02CU0 0.999 Q02CU0 →
Q2A1F3 0.999 Q2A1F3 →