SCHEMBL807308

SCHEMBL807308

c1ccc(CN2CCOc3ccc(Oc4ccccc4-c4ccccc4)cc3C2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.47
CYP3A4 P08684 1/20 0.47
HIF1A Q16665 1/20 0.47
PTGER2 P43116 6/20 0.44
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
HTT P42858 1/20 0.40
FFAR1 O14842 1/20 0.40
CHRM2 P08172 1/20 0.39
HTR1A P08908 1/20 0.39
CHRM3 P20309 1/20 0.39
DRD4 P21917 1/20 0.39
ADRA1D P25100 1/20 0.39
HTR2C P28335 1/20 0.39
ADRA1A P35348 1/20 0.39
ADRA1B P35368 1/20 0.39
DRD3 P35462 1/20 0.39
HTR2B P41595 1/20 0.39
SLC6A3 Q01959 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL807032 0.81 CYP2D6 (0.53) CYP2D6CYP3A4HIF1APTGER2CHRM2
SCHEMBL3276408 0.74 CYP2D6 (0.51) CYP2D6CYP3A4HIF1APTGER2ALDH1A1
SCHEMBL6436620 0.73 CYP2D6 (0.51) CYP2D6HTR1ADRD4HTR2BTMEM97
SCHEMBL807306 0.73 CYP2D6 (0.53) CYP2D6PTGER2ALDH1A1HTR1ASIGMAR1
SCHEMBL807150 0.72 PTGER2 (0.59) CYP2D6PTGER2
SCHEMBL807310 0.71 CYP2D6 (0.48) CYP2D6CYP3A4HIF1APTGER2ALDH1A1
SCHEMBL14023200 0.71 ALDH1A1 (0.53) CYP2D6CYP3A4HIF1APTGER2KDM4E
SCHEMBL4788136 0.71 DRD2 (0.51) CYP2D6CYP3A4HIF1APTGER2ALDH1A1
SCHEMBL807305 0.71 SIGMAR1 (0.71) CYP2D6PTGER2KDM4EALDH1A1HPGD
SCHEMBL807148 0.70 CYP2D6 (0.49) CYP2D6CYP3A4HIF1APTGER2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012037105-A1 METHODS OF TREATING, AMELIORATING OR PREVENTING STRESS-INDUCED NEURONAL DISORDERS AND DISEASES THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-03-22 WO disclosed
WO-2012019076-A1 COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CARDIAC ISCHEMIA/REPERFUSION INJURY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-09 WO disclosed
WO-2012019071-A1 METHODS OF PREVENTING AND TREATING SARCOPENIA THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-02-09 WO disclosed
WO-2008144483-A2 AGENTS FOR TREATING DISORDERS INVOLVING MODULATION OF RYANODINE RECEPTORS ARMGO PHARMA, INC. (US) 2008-11-27 WO disclosed