Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 10/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CASR | P41180 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954714 | 1.00 | TBXAS1 (0.49) | TBXAS1CYP2D6SLC6A2SLC6A4CASR | |
| SCHEMBL8193847 | 0.88 | NAMPT (0.50) | CYP2D6MEN1KMT2ANAMPTADRB1 | |
| SCHEMBL8193844 | 0.88 | NAMPT (0.50) | CYP2D6MEN1KMT2ANAMPTADRB1 | |
| SCHEMBL8193726 | 0.85 | ALDH1A1 (0.51) | TBXAS1CYP2D6SLC6A2SLC6A4CASR | |
| SCHEMBL8193727 | 0.85 | ALDH1A1 (0.51) | TBXAS1CYP2D6SLC6A2SLC6A4CASR | |
| SCHEMBL8479757 | 0.84 | POLB (0.52) | CASRMEN1KMT2ANAMPTALDH1A1 | |
| SCHEMBL8477139 | 0.84 | ALOX5 (0.49) | MEN1KMT2ANAMPTALDH1A1 | |
| SCHEMBL8480213 | 0.84 | ALOX5 (0.49) | MEN1KMT2ANAMPTALDH1A1 | |
| SCHEMBL8476796 | 0.83 | ALDH1A1 (0.45) | MEN1KMT2ANAMPTALDH1A1ADRB1 | |
| SCHEMBL8551329 | 0.83 | ALDH1A1 (0.45) | MEN1KMT2ANAMPTALDH1A1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019375-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-07-19 | — | — | EP | claimed |
| WO-1998042669-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |
| WO-2000061560-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-10-19 | — | — | WO | disclosed |
| EP-1019375-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998042669-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | disclosed |