Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074970 | 0.90 | SLC6A2 (0.45) | SLC6A2SLC6A4LPAR1LPAR5SIRT1 | |
| Hydrochloric Acid SCHEMBL8070331 | 0.89 | SLC6A2 (0.44) | SLC6A2SLC6A4LPAR1LPAR5SIRT1 | |
| SCHEMBL8059455 | 0.86 | HRH3 (0.40) | SLC6A2SLC6A4DRD2DRD3HRH3 | |
| SCHEMBL8068477 | 0.83 | DRD2 (0.38) | SLC6A2SLC6A4DRD2DRD3HRH3 | |
| SCHEMBL8068627 | 0.81 | LPAR1 (0.48) | SLC6A2SLC6A4LPAR1LPAR5SIRT1 | |
| Hydrochloric Acid SCHEMBL8059587 | 0.78 | SIRT1 (0.42) | SLC6A2SLC6A4LPAR1LPAR5SIRT1 | |
| SCHEMBL8444238 | 0.78 | SLC6A2 (0.41) | SLC6A2SLC6A4LPAR1LPAR5SIRT1 | |
| SCHEMBL8428715 | 0.78 | SIRT1 (0.46) | SIRT1THRBROCK2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL8070897 | 0.77 | SLC6A2 (0.40) | SLC6A2SLC6A4LPAR1LPAR5SIRT1 | |
| Hydrochloric Acid SCHEMBL8426168 | 0.77 | SIRT1 (0.46) | SIRT1THRBROCK2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |