Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.48 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ESRRA | P11474 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068670 | 0.86 | NOTUM (0.43) | LPAR1LPAR5SLC6A2SLC6A4NOTUM | |
| SCHEMBL8068454 | 0.84 | THRA (0.44) | SLC6A2SLC6A4NOTUMMRGPRX4THRA | |
| SCHEMBL12239037 | 0.84 | LOXL2 (0.55) | SLC6A2SLC6A4NOTUMMRGPRX4CYP3A4 | |
| SCHEMBL8074970 | 0.83 | SLC6A2 (0.45) | LPAR1LPAR5SLC6A2SLC6A4THRA | |
| Hydrochloric Acid SCHEMBL8070331 | 0.83 | SLC6A2 (0.44) | LPAR1LPAR5SLC6A2SLC6A4THRA | |
| SCHEMBL8070159 | 0.82 | FFAR1 (0.42) | LPAR1LPAR5SLC6A2SLC6A4MRGPRX4 | |
| SCHEMBL8075018 | 0.81 | SLC6A2 (0.43) | LPAR1LPAR5SLC6A2SLC6A4THRA | |
| SCHEMBL8068481 | 0.80 | THRA (0.43) | LPAR1LPAR5SLC6A2SLC6A4THRA | |
| SCHEMBL8075068 | 0.80 | NOTUM (0.54) | NOTUMMRGPRX4CYP3A4ESRRAALDH1A1 | |
| SCHEMBL8068832 | 0.79 | PKM (0.43) | LPAR1LPAR5ALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |