Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12263154 | 0.88 | TTR (0.37) | TRPV4TTRALBGAASMN1; SMN2 | |
| SCHEMBL13748207 | 0.82 | TRPV4 (0.35) | TRPV4CYP11B1CYP11B2ADRB2ADRB1 | |
| SCHEMBL807272 | 0.81 | MET (0.36) | TTRALBGAASMN1; SMN2VCAM1 | |
| SCHEMBL26457748 | 0.81 | CYP11B1 (0.35) | TRPV4CYP11B1CYP11B2ADRB2ADRB1 | |
| SCHEMBL26080843 | 0.81 | EGLN2 (0.37) | TTRALBGAASMN1; SMN2FFAR1 | |
| SCHEMBL24606679 | 0.81 | ADRB2 (0.40) | TRPV4CYP11B1CYP11B2ADRB2ADRB1 | |
| SCHEMBL18999982 | 0.80 | TRPV4 (0.41) | TRPV4CYP11B1CYP11B2ADRB2ADRB1 | |
| SCHEMBL18612531 | 0.79 | TRPV4 (0.31) | TRPV4TTRALBGAASMN1; SMN2 | |
| SCHEMBL21756945 | 0.79 | TRPV4 (0.33) | TRPV4CYP11B1CYP11B2ADRB2ADRB1 | |
| SCHEMBL26458345 | 0.79 | KHK (0.36) | TRPV4CYP11B1CYP11B2KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |