Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | KMO | O15229 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | CES1 | P23141 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967701 | 1.00 | TSHR (0.67) | TSHRKMOKMT2AMEN1MAPT | |
| SCHEMBL6276435 | 1.00 | TSHR (0.67) | TSHRKMOKMT2AMEN1MAPT | |
| SCHEMBL5313340 | 0.82 | TSHR (0.72) | TSHRKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL1606582 | 0.82 | TSHR (0.65) | TSHRKMT2AMEN1MAPTMAPK1 | |
| SCHEMBL14889161 | 0.82 | KMO (0.67) | KMOKMT2AMAPTGSK3BL3MBTL1 | |
| SCHEMBL9420250 | 0.82 | KMO (0.57) | TSHRKMOMAPTSMN1; SMN2KDM4E | |
| SCHEMBL8223279 | 0.82 | KMO (0.57) | TSHRKMOKMT2AMEN1KDM4E | |
| SCHEMBL10782076 | 0.82 | ALDH1A1 (0.58) | TSHRKMOKMT2AMEN1MAPT | |
| SCHEMBL1548812 | 0.82 | KMO (0.67) | KMOKMT2AMAPTGSK3BL3MBTL1 | |
| SCHEMBL728409 | 0.81 | KMO (0.66) | TSHRKMOKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1295555-A | Process for preparation of HPB esters | CIBA SC HOLDING AG (CH) | 2001-05-16 | — | — | CN | claimed |
| EP-4313986-A1 | PROCESSES FOR MAKING BICYCLIC KETONE COMPOUNDS | Genentech, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| US-20240034739-A1 | PROCESSES FOR MAKING BICYCLIC KETONE COMPOUNDS | GENENTECH, INC. (US) | 2024-02-01 | — | — | US | disclosed |
| CN-117098762-A | Process for preparing bicyclic ketone compounds | 基因泰克公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-102586349-B | Preparation method of ethyl (R)-2-hydroxyl-4-phenylbutyrate by combining microbe reduction and chemical catalytic hydrogenation | UNIV CHONGQING POSTS & TELECOM | 2014-12-03 | — | — | CN | disclosed |
| CN-101462947-B | Preparation of (R) -4-phenyl-2-hydroxybutyrate | SHANGHAI BAIDING PHARMACEUTICAL TECHNOLOGY CO LTD | 2012-07-25 | — | — | CN | disclosed |
| CN-102586349-A | Preparation method of ethyl (R)-2-hydroxyl-4-phenylbutyrate by combining microbe reduction and chemical catalytic hydrogenation | UNIV CHONGQING POSTS & TELECOM | 2012-07-18 | — | — | CN | disclosed |
| CN-101462947-A | Preparation of (R) -4-phenyl-2-hydroxybutyrate | SHANGHAI BAIDING PHARMACEUTICA (CN) | 2009-06-24 | — | — | CN | disclosed |
| CN-1370767-A | Synthesis of optically pure R-and S-2-hydroxyl-4-aryl butyric acid | CHENGDU ORGANIC CHEM INST (CN) | 2002-09-25 | — | — | CN | disclosed |
| CN-1295555-A | Process for preparation of HPB esters | CIBA SC HOLDING AG (CH) | 2001-05-16 | — | — | CN | disclosed |
| EP-0620857-B1 | SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS | GENZYME LTD (GB) | 2000-08-02 | — | — | EP | disclosed |
| US-5686275-A | LACTATE DEHYDROGENASE | GENZYME LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0620857-A1 | SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS | Genzyme Limited (GB) | 1994-10-26 | — | — | EP | disclosed |
| WO-1993013215-A1 | SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS | GENZYME LIMITED (GB) | 1993-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240034739-A1 | PROCESSES FOR MAKING BICYCLIC KETONE COMPOUNDS | HSD17B7, BCKDK, CYP11B1 | TSHR 2458/4885KMO 90/4885KMT2A 1607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.