Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23182676 | 0.89 | DRD2 (0.36) | HTR2AHTR2C | |
| SCHEMBL13767655 | 0.89 | SLC18A3 (0.36) | HTR2CSLC18A3SIGMAR1BCHEACHE | |
| SCHEMBL14208047 | 0.78 | HTR6 (0.36) | SLC18A3 | |
| SCHEMBL13091092 | 0.76 | — | — | |
| SCHEMBL24446604 | 0.73 | SLC6A2 (0.30) | — | |
| SCHEMBL2323264 | 0.72 | — | — | |
| SCHEMBL787463 | 0.72 | — | — | |
| SCHEMBL29859614 | 0.72 | SLC18A3 (0.35) | HTR2CSLC18A3SIGMAR1BCHEACHE | |
| SCHEMBL6083553 | 0.69 | HTR3A (0.44) | HTR3APDE4BHTR2AHTR2C | |
| SCHEMBL15930175 | 0.69 | ESR2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012036997-A1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | SCHERING CORPORATION (US) | 2012-03-22 | — | — | WO | disclosed |