Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | ADK | P55263 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9141298 | 0.91 | ABCC9 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8077246 | 0.84 | HSD11B1 (0.34) | TRPV1HSD11B1ALDH1A1 | |
| SCHEMBL8122910 | 0.84 | TRPV1 (0.32) | F10TRPV1TP53 | |
| SCHEMBL8084219 | 0.83 | KDM4E (0.36) | F10ADKALDH1A1 | |
| SCHEMBL9475113 | 0.82 | ESPL1 (0.37) | ALDH1A1 | |
| SCHEMBL8085076 | 0.82 | NPSR1 (0.34) | F10TRPV1AR | |
| SCHEMBL8084230 | 0.82 | HRH4 (0.30) | AR | |
| SCHEMBL9796819 | 0.82 | HRH4 (0.34) | PPARGTP53ALDH1A1 | |
| SCHEMBL8088499 | 0.82 | TP53 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9299404 | 0.81 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373204-A1 | NOVEL COMPOUNDS AND TREATMENT | BEECHAM GROUP PLC (GB) | 1990-06-20 | — | — | EP | claimed |
| WO-1989010925-A1 | NOVEL COMPOUNDS AND TREATMENT | BEECHAM GROUP PLC (GB) | 1989-11-16 | — | — | WO | claimed |
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5254557-A | Administering for reversible airways obstruction and asthma | BEECHAM GROUP P.L.C. (GB) | 1993-10-19 | — | — | US | disclosed |
| EP-0373204-A1 | NOVEL COMPOUNDS AND TREATMENT | BEECHAM GROUP PLC (GB) | 1990-06-20 | — | — | EP | disclosed |
| WO-1989010925-A1 | NOVEL COMPOUNDS AND TREATMENT | BEECHAM GROUP PLC (GB) | 1989-11-16 | — | — | WO | disclosed |