Sugi Predict

Sugi Predict / Compounds / SCHEMBL807727

SCHEMBL807727

SCHEMBL807727

COc1ccc(-c2nc(-c3ccc(-c4ccccc4)cc3)nc(-c3ccc(-c4ccccc4)cc3)n2)c(O)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 4/20 0.59
▸ MAPT P10636 5/20 0.53
▸ MEN1 O00255 4/20 0.53
▸ KMT2A Q03164 4/20 0.53
▸ SMN1; SMN2 Q16637 3/20 0.53
▸ RAB9A P51151 2/20 0.53
▸ NFKB1 P19838 1/20 0.53
▸ NFKB2 Q00653 1/20 0.53
▸ RELA Q04206 1/20 0.53
▸ PTPN1 P18031 1/20 0.53
▸ BACE1 P56817 1/20 0.53
▸ NCOA1 Q15788 2/20 0.52
▸ NCOA3 Q9Y6Q9 2/20 0.52
▸ IDH1 O75874 1/20 0.51
▸ HTT P42858 3/20 0.50
▸ ALDH1A1 P00352 2/20 0.50
▸ TP53 P04637 2/20 0.50
▸ KDM4E B2RXH2 2/20 0.50
▸ HSD17B10 Q99714 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15910010 1.00 NPC1 (0.59) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL195208 0.97 NPC1 (0.59) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL17920176 0.97 NPC1 (0.62) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL39669 0.97 NPC1 (0.62) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL29353657 0.97 NPC1 (0.62) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL13938599 0.94 NPC1 (0.61) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL15908134 0.93 NPC1 (0.52) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL17571546 0.93 TSHR (0.59) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL8332568 0.92 MAPT (0.56) NPC1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL12997145 0.92 NPC1 (0.54) NPC1MAPTMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9156966-B2 Addition of non-reactive UV absorbers during polyester synthesis TORAY PLASTICS (AMERICA), INC. (US) 2015-10-13 — — US disclosed
US-20150183957-A1 ADDITION OF NON-REACTIVE UV ABSORBERS DURING POLYESTER SYNTHESIS TORAY PLASTICS (AMERICA), INC. (US) 2015-07-02 — — US disclosed
US-8986662-B2 Use of silane and siloxane bis(biphenyl) triazine derivatives as UV absorbers BASF SE (DE) 2015-03-24 — — US disclosed
US-8895137-B2 Scratch resistant top coats having good adhesion BAYER MATERIALSCIENCE AG (DE) 2014-11-25 — — US disclosed
US-8895137-B2 Scratch resistant top coats having good adhesion BAYER MATERIALSCIENCE AG (DE) 2014-11-25 — — US disclosed
EP-2414894-B1 UV-DOSE INDICATOR FILMS BASF SE (DE) 2014-02-12 — — EP disclosed
US-8585782-B2 Use of specific bis(biphenyl)triazine derivatives and mixtures thereof as UV absorbers BASF SE (DE) 2013-11-19 — — US disclosed
US-8585782-B2 Use of specific bis(biphenyl)triazine derivatives and mixtures thereof as UV absorbers BASF SE (DE) 2013-11-19 — — US disclosed
US-20130202542-A1 USE OF SILANE AND SILOXANE BIS(BIPHENYL) TRIAZINE DERIVATIVES AS UV ABSORBERS BASF SE (DE) 2013-08-08 — — US disclosed
US-20130164231-A1 Use of specific bis(biphenyl)triazine derivatives and mixtures thereof as UV absorbers BASF SE (DE) 2013-06-27 — — US disclosed
US-20050019281-A1 Biphenyl-substituted triazines FLETCHER IAN JOHN (CH) 2005-01-27 — — US disclosed
US-6841670-B2 High thermal stability, are used as stabilizers for organic polymers to counter damage thereto caused by light, oxygen and heat, as light stabilizers for textile fiber materials and as sunscreens for the human skin. CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-01-11 — — US disclosed
US-20030045444-A1 Biphenyl-substituted triazines FLETCHER IAN JOHN (CH) 2003-03-06 — — US disclosed
US-6468958-B2 LIGHT, OXYGEN AND HEAT RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION 2002-10-22 — — US disclosed
EP-0815089-B1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER CIBA SC HOLDING AG (CH) 2002-09-25 — — EP disclosed
US-20010039341-A1 Biphenyl-Substituted Triazines FLETCHER IAN JOHN (CH) 2001-11-08 — — US disclosed
US-6255483-B1 USEFUL AS LIGHT STABILIZERS FOR TEXTILE FIBER MATERIALS AND SUNSCREENS FOR HUMAN SKIN CIBA SPECIALTY CHEMICALS CORPORATION 2001-07-03 — — US disclosed
US-5998116-A TRIAZINE UV ABSORBERS CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-12-07 — — US disclosed
EP-0815089-A1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER Ciba SC Holding AG (CH) 1998-01-07 — — EP disclosed
WO-1996028431-A1 BIPHENYL-SUBSTITUTED TRIAZINES AS LIGHT STABILIZER CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 1996-09-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050019281-A1 Biphenyl-substituted triazines TYR, AHR, CUTA NPC1 4339/4885MAPT 60/4885MEN1 4517/4885
US-20130164231-A1 Use of specific bis(biphenyl)triazine derivatives and mixtures thereof as UV absorbers NR1H2, CBR3, NR1H3 NPC1 1895/4885MAPT 4821/4885MEN1 4239/4885
US-20030045444-A1 Biphenyl-substituted triazines TYR, CYP1B1, NFE2L2 NPC1 3852/4885MAPT 111/4885MEN1 4123/4885
US-20130202542-A1 USE OF SILANE AND SILOXANE BIS(BIPHENYL) TRIAZINE DERIVATIVES AS UV ABSORBERS CCNL2, MSR1, CYP2S1 NPC1 2403/4885MAPT 4472/4885MEN1 3254/4885
US-20010039341-A1 Biphenyl-Substituted Triazines TYR, CYP1B1, NFE2L2 NPC1 3852/4885MAPT 111/4885MEN1 4123/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.