Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090547 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL8084424 | 0.87 | KMT2A (0.41) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL8085417 | 0.86 | MALT1 (0.37) | KMT2AMAPTMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8085063 | 0.85 | CA9 (0.35) | KMT2AMAPTMEN1ALDH1A1GAA | |
| SCHEMBL8090686 | 0.84 | CA9 (0.42) | KMT2AMEN1ALDH1A1PKMTDP1 | |
| SCHEMBL8085054 | 0.83 | ALDH1A1 (0.35) | KMT2AMAPTMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8085089 | 0.83 | MEN1 (0.37) | KMT2AMAPTMEN1ALDH1A1GAA | |
| SCHEMBL7276803 | 0.82 | DRD2 (0.37) | SMN1; SMN2KMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL8090742 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL8085097 | 0.81 | CFTR (0.38) | SMN1; SMN2KMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |