Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.37 |
| ▸ | DRD3 | P35462 | 6/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085132 | 0.87 | EGLN2 (0.39) | DRD2DRD3EGLN2ABCC9KDM4E | |
| SCHEMBL8077023 | 0.87 | EGLN2 (0.36) | DRD2DRD3EGLN2KDM1AABCC9 | |
| SCHEMBL8085328 | 0.85 | ABCC9 (0.36) | ABCC9KDM4ECYP2C19 | |
| SCHEMBL8090111 | 0.84 | RARA (0.36) | ABCC9KDM4EALDH1A1CYP2C19 | |
| SCHEMBL7267033 | 0.83 | MALT1 (0.35) | KDM1AABCC9CYP2C19 | |
| SCHEMBL8077233 | 0.83 | ABCC9 (0.40) | ABCC9 | |
| SCHEMBL8077323 | 0.82 | SMN1; SMN2 (0.40) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL8088372 | 0.81 | PDE4A (0.39) | DRD2DRD3EGLN2PGRKDM1A | |
| SCHEMBL8084526 | 0.81 | ABCC9 (0.36) | DRD2DRD3EGLN2ABCC9KDM4E | |
| SCHEMBL8084925 | 0.81 | EGLN2 (0.33) | DRD2DRD3EGLN2ABCC9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0346724-A1 | Chroman derivates | MERCK PATENT GmbH (DE) | 1989-12-20 | — | — | EP | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |