Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779863 | 0.81 | LMNA (0.44) | CTSKKDM4CGPR142ALDH1A1SMN1; SMN2 | |
| SCHEMBL6099838 | 0.78 | NPSR1 (0.52) | CTSKKDM4CGPR142ALDH1A1SMN1; SMN2 | |
| SCHEMBL20769320 | 0.77 | MAPK1 (0.44) | CTSKKDM4CGPR142ALDH1A1SMN1; SMN2 | |
| SCHEMBL17025004 | 0.75 | KDM4C (0.51) | CTSKKDM4CGPR142ALDH1A1ADORA2A | |
| SCHEMBL17038776 | 0.75 | PDE10A (0.45) | CTSKKDM4CGPR142ALDH1A1SMN1; SMN2 | |
| SCHEMBL9079443 | 0.74 | KDM4C (0.42) | HPGDCTSKKDM4CGPR142SMN1; SMN2 | |
| SCHEMBL30223118 | 0.74 | KDM4C (0.47) | CTSKKDM4CGPR142ADORA2AADORA1 | |
| SCHEMBL7281500 | 0.74 | EPHX2 (0.52) | CTSK | |
| SCHEMBL12265803 | 0.73 | KDM4C (0.43) | CTSKKDM4CGPR142ALDH1A1SMN1; SMN2 | |
| SCHEMBL13774772 | 0.73 | ALDH1A1 (0.67) | HPGDALDH1A1SMN1; SMN2CYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009061448-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROTEINURIC DISEASES | THE GENERAL HOSPITAL CORPORATION (US) | 2009-05-14 | — | — | WO | disclosed |