Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | APP | P05067 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 2/20 | 0.52 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.52 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.52 |
| ▸ | ITGAL | P20701 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8077994 | 1.00 | TRPV1 (0.66) | TRPV1KDM4EKMT2AAPPHPGD | |
| SCHEMBL9363901 | 0.87 | TRPV1 (0.81) | TRPV1KDM4EKMT2AAPPHPGD | |
| SCHEMBL9364141 | 0.87 | TRPV1 (0.81) | TRPV1KDM4EKMT2AAPPHPGD | |
| SCHEMBL4409428 | 0.82 | KDM4E (0.80) | KDM4EHPGDSMN1; SMN2ALDH1A1CNR2 | |
| SCHEMBL4409431 | 0.82 | KDM4E (0.80) | KDM4EHPGDSMN1; SMN2ALDH1A1CNR2 | |
| SCHEMBL14441230 | 0.80 | RAB9A (0.91) | TRPV1KDM4EKMT2AHPGDMEN1 | |
| SCHEMBL2122038 | 0.80 | TRPV1 (1.00) | TRPV1KDM4EKMT2AAPPHPGD | |
| SCHEMBL2122045 | 0.80 | TRPV1 (1.00) | TRPV1KDM4EKMT2AAPPHPGD | |
| SCHEMBL8085980 | 0.80 | KDM4E (0.76) | KDM4EKMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL8085985 | 0.80 | KDM4E (0.76) | KDM4EKMT2AHPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017919-A | Compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2000-01-25 | — | — | US | disclosed |
| EP-0887340-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco Inc. (JP) | 1998-12-30 | — | — | EP | disclosed |