Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3065623 | 0.94 | LMNA (0.42) | SMN1; SMN2MEN1CYP2C19KMT2ALMNA | |
| SCHEMBL3058644 | 0.84 | P2RX3 (0.40) | P2RX3 | |
| SCHEMBL3048678 | 0.78 | HDAC6 (0.49) | SMN1; SMN2MEN1CYP2C19KMT2ALMNA | |
| SCHEMBL3044391 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1CYP2C19KMT2ALMNA | |
| SCHEMBL3060167 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1CYP2C19KMT2ALMNA | |
| SCHEMBL3050216 | 0.70 | LIPG (0.51) | MEN1KMT2ANPSR1TP53LIPG | |
| SCHEMBL3065624 | 0.70 | P2RX3 (0.35) | LMNAP2RX3TP53TDP1 | |
| SCHEMBL6336837 | 0.67 | LIPG (0.48) | LIPG | |
| SCHEMBL3053596 | 0.66 | EP300 (0.42) | SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL8084507 | 0.66 | RXRA (0.47) | HTTMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026446-A9 | HDAC INHIBITORS | ARQULE, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2009026446-A2 | HDAC INHIBITORS | ARQULE, INC. (US) | 2009-02-26 | — | — | WO | disclosed |