Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2399270 | 0.83 | APP (0.37) | MAPTNPC1ALDH1A1HTTRAB9A | |
| SCHEMBL2370319 | 0.79 | LMNA (0.42) | MAPTNPC1ALDH1A1RAB9ATP53 | |
| SCHEMBL2370368 | 0.78 | ITK (0.47) | MAPTNPC1RAB9ATP53RXFP1 | |
| SCHEMBL2370365 | 0.78 | ITK (0.47) | MAPTNPC1RAB9ATP53RXFP1 | |
| SCHEMBL2371227 | 0.75 | APP (0.37) | MAPTNPC1ALDH1A1HTTRAB9A | |
| SCHEMBL2371233 | 0.74 | HTT (0.45) | MAPTALDH1A1HTTRAB9ARXFP1 | |
| SCHEMBL2370208 | 0.73 | ALDH1A1 (0.44) | MAPTALDH1A1HTTRXFP1 | |
| SCHEMBL807801 | 0.69 | LMNA (0.42) | MAPTTP53RXFP1 | |
| SCHEMBL2425957 | 0.67 | PIK3CG (0.43) | — | |
| SCHEMBL2425952 | 0.67 | PIK3CG (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035055-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-03-22 | — | — | WO | disclosed |