Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCLAT1 | Q6UWP7 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 10/20 | 0.41 |
| ▸ | RAB9A | P51151 | 10/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL795710 | 0.89 | CASP3 (0.43) | NPC1RAB9ASMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL796526 | 0.88 | CASP3 (0.50) | LCLAT1NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL795322 | 0.82 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL796382 | 0.82 | NPC1 (0.41) | LCLAT1NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL795193 | 0.78 | CASP3 (0.44) | NPC1RAB9ASMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL795357 | 0.78 | ADORA2A (0.47) | NPC1RAB9ASMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL795418 | 0.78 | SMN1; SMN2 (0.41) | LCLAT1NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL795637 | 0.78 | MAPT (0.43) | NPC1RAB9ASMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL795831 | 0.77 | CASP3 (0.48) | LCLAT1NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL795092 | 0.71 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-B1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2015-11-04 | — | — | EP | disclosed |
| US-20150025057-A1 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2015-01-22 | — | — | US | disclosed |
| US-8895733-B2 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-20140051676-A1 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2014-02-20 | — | — | US | disclosed |
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025057-A1 | Triazine-oxadiazoles | OPRK1, OPRD1, OPRL1 | LCLAT1 3387/4885NPC1 3204/4885RAB9A 4766/4885 |
| US-20140051676-A1 | Triazine-oxadiazoles | OPRK1, OPRD1, OPRL1 | LCLAT1 3387/4885NPC1 3204/4885RAB9A 4766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.