Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323146 | 0.77 | AKT1 (0.50) | RIPK1MAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL28116359 | 0.74 | RIPK1 (0.62) | RIPK1ALOX5MAPTNPSR1POLB | |
| SCHEMBL6235763 | 0.73 | RIPK1 (0.50) | RIPK1MAPTNPSR1POLBTSHR | |
| SCHEMBL8064136 | 0.73 | ALOX5 (0.46) | ALOX5TSHRALDH1A1 | |
| SCHEMBL29206617 | 0.70 | RIPK1 (0.57) | RIPK1ALOX5MAPTNPSR1TSHR | |
| SCHEMBL10223246 | 0.70 | RIPK1 (0.75) | RIPK1ALOX5MAPTNPSR1POLB | |
| SCHEMBL24391228 | 0.70 | RIPK1 (0.61) | RIPK1ALOX5MAPTNPSR1POLB | |
| SCHEMBL21393181 | 0.70 | MAPK1 (0.66) | RIPK1ALOX5MAPTNPSR1POLB | |
| SCHEMBL11050213 | 0.69 | THRA (0.55) | RIPK1ALOX5MAPTNPSR1POLB | |
| SCHEMBL13887643 | 0.69 | RIPK1 (0.46) | RIPK1ALOX5MAPTNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103721-A | TREATMENT OF STROKE ANOXIA; ANTIHYPERGLYCEMIC,-ISCHEMIC AND -EPILEPTIC AGENTS | ZENECA LIMITED (GB) | 2000-08-15 | — | — | US | disclosed |