Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079441 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2TYRTSHRMMEALDH1A1 | |
| SCHEMBL18190838 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2TYRTSHRMMEALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7349072 | 0.89 | SMN1; SMN2 (0.43) | SMN1; SMN2TYRTSHRMMEALDH1A1 | |
| SCHEMBL12514588 | 0.83 | PLG (0.48) | SMN1; SMN2MMEACECPA1ACE2 | |
| SCHEMBL3551870 | 0.81 | TYR (0.44) | SMN1; SMN2TYRTSHRMMEALDH1A1 | |
| SCHEMBL10513380 | 0.81 | TYR (0.44) | SMN1; SMN2TYRTSHRMMEALDH1A1 | |
| SCHEMBL753926 | 0.81 | TYR (0.44) | SMN1; SMN2TYRTSHRMMEALDH1A1 | |
| SCHEMBL8253529 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2TSHRALDH1A1MAPTKDM4E | |
| SCHEMBL5551991 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2TYRTSHRALDH1A1MAPT | |
| SCHEMBL6900418 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2TSHRALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12583849-B2 | KCNT1 inhibitors and methods of use | PRAXIS PRECISION MEDICINES, INC. (US) | 2026-03-24 | — | — | US | disclosed |
| EP-4692069-A2 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| EP-4110317-B1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PREC MEDICINES INC (US) | 2025-11-19 | — | — | EP | disclosed |
| US-20250122149-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XWPharma Ltd. (KY) | 2025-04-17 | — | — | US | disclosed |
| US-12209060-B2 | Ketamine derivatives and compositions thereof | XWPharma Ltd. (KY) | 2025-01-28 | — | — | US | disclosed |
| US-20230167102-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-06-01 | — | — | US | disclosed |
| US-20220411365-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XWPharma Ltd. (KY) | 2022-12-29 | — | — | US | disclosed |
| WO-2022231872-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2022-11-03 | — | — | WO | disclosed |
| US-11440874-B2 | Ketamine derivatives and compositions thereof | XWPharma Ltd. (KY) | 2022-09-13 | — | — | US | disclosed |
| CN-112135812-B | Ketamine derivatives and pharmaceutical compositions thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2022-01-18 | — | — | CN | disclosed |
| CN-112135812-A | Ketamine derivatives and pharmaceutical compositions thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2020-12-25 | — | — | CN | disclosed |
| US-10836714-B2 | Ketamine derivatives and compositions thereof | XW LABORATORIES INC. (KY) | 2020-11-17 | — | — | US | disclosed |
| US-20200231540-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XW LABORATORIES INC. (KY) | 2020-07-23 | — | — | US | disclosed |
| US-10683262-B2 | Ketamine derivatives and compositions thereof | XW LABORATORIES INC. (KY) | 2020-06-16 | — | — | US | disclosed |
| US-20190322618-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | XWPharma Ltd. (KY) | 2019-10-24 | — | — | US | disclosed |
| EP-3389643-A1 | NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF | Bharat Biotech International Limited (IN) | 2018-10-24 | — | — | EP | disclosed |
| EP-3387005-A1 | NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF | Bharat Biotech International Limited (IN) | 2018-10-17 | — | — | EP | disclosed |
| WO-2017103944-A1 | NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF | BHARAT BIOTECH INTERNATIONAL LIMITED (IN) | 2017-06-22 | — | — | WO | disclosed |
| WO-2017098529-A1 | NOVEL MURAMYL PEPTIDE DERIVATIVE COMPOUND, SYNTHESIS AND USES THEREOF | BHARAT BIOTECH INTERNATIONAL LIMITED (IN) | 2017-06-15 | — | — | WO | disclosed |
| US-6043376-A | Synthesis of alpha-methyl, alpha-substituted amino acids | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2000-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12583849-B2 | KCNT1 inhibitors and methods of use | KCNT1, SCN1A, KCNT2 | SMN1; SMN2 229/4885TYR 3533/4885TSHR 3457/4885 |
| US-12209060-B2 | Ketamine derivatives and compositions thereof | OPRK1, KCNK10, KCNK17 | SMN1; SMN2 581/4885TYR 967/4885TSHR 4618/4885 |
| US-20190322618-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | OPRK1, KCNK10, KCNK17 | SMN1; SMN2 581/4885TYR 967/4885TSHR 4618/4885 |
| US-11440874-B2 | Ketamine derivatives and compositions thereof | OPRK1, KCNK10, KCNK17 | SMN1; SMN2 581/4885TYR 967/4885TSHR 4618/4885 |
| US-20230167102-A1 | KCNT1 INHIBITORS AND METHODS OF USE | KCNT1, KCNT2, KCNQ2 | SMN1; SMN2 423/4885TYR 3194/4885TSHR 3515/4885 |
| US-10683262-B2 | Ketamine derivatives and compositions thereof | OPRK1, KCNK10, KCNK17 | SMN1; SMN2 581/4885TYR 967/4885TSHR 4618/4885 |
| US-20200231540-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | OPRK1, KCNK10, KCNK17 | SMN1; SMN2 581/4885TYR 967/4885TSHR 4618/4885 |
| US-20250122149-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | OPRK1, KCNK10, KCNK17 | SMN1; SMN2 581/4885TYR 967/4885TSHR 4618/4885 |
| US-20220411365-A1 | KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF | OPRK1, KCNK10, KCNK17 | SMN1; SMN2 581/4885TYR 967/4885TSHR 4618/4885 |
| US-10836714-B2 | Ketamine derivatives and compositions thereof | OPRK1, KCNK10, KCNK17 | SMN1; SMN2 581/4885TYR 967/4885TSHR 4618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.