Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.45 |
| ▸ | PI4KA | P42356 | 11/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 11/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.44 |
| ▸ | PIP5K1C | O60331 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131809 | 0.87 | PIK3CA (0.43) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL807826 | 0.82 | PI4KA (0.45) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL15131803 | 0.81 | MAP4K4 (0.44) | PIK3CBQPCTMAP4K4ALDH1A1CYP3A4 | |
| SCHEMBL10070633 | 0.81 | PI4KA (0.46) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL15131799 | 0.80 | PI4KA (0.48) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL807982 | 0.79 | MET (0.45) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL807817 | 0.78 | PI4KA (0.52) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL807988 | 0.78 | GRIN1 (0.42) | PIK3CAPIK3CBMAP4K4CYP3A4 | |
| SCHEMBL3706737 | 0.70 | PIK3CG (0.61) | PIK3CAPI4KAPI4KBPIK3CDPIK3CG | |
| SCHEMBL807983 | 0.69 | PIK3CA (0.43) | PIK3CAPI4KBPIK3CDPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181264-B2 | Fused heteroaryls and their uses | HUTCHISON MEDIPHARMA LIMITED (CN) | 2015-11-10 | — | — | US | disclosed |
| US-9181264-B2 | Fused heteroaryls and their uses | HUTCHISON MEDIPHARMA LIMITED (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-07-25 | — | — | US | disclosed |
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2013-07-25 | — | — | US | disclosed |
| WO-2012034526-A1 | FUSED HETEROARYLS AND THEIR USES | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190307-A1 | FUSED HETEROARYLS AND THEIR USES | FARS2, TIAL1, DHFR | PIK3CA 1962/4885PI4KA 2058/4885PI4KB 1421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.