SCHEMBL807994

SCHEMBL807994

C=C(/N=C(N)\N=C(/N)c1noc(-c2nccs2)n1)N(C)c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.31
PDPK1 O15530 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL808229 0.82 SIGMAR1 (0.32) SIGMAR1
SCHEMBL808221 0.80 SIGMAR1 (0.32) SIGMAR1
SCHEMBL808333 0.79 NPC1 (0.37) SIGMAR1
SCHEMBL807976 0.79 SIGMAR1 (0.31) SIGMAR1
SCHEMBL10287560 0.78 HDAC4 (0.33)
SCHEMBL807906 0.78 SMN1; SMN2 (0.40)
SCHEMBL808224 0.78 SIGMAR1 (0.32) SIGMAR1
SCHEMBL808235 0.78 HDAC6 (0.34) SIGMAR1
SCHEMBL10287187 0.78 ALDH1A1 (0.45)
SCHEMBL807993 0.78 GRM5 (0.39) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012035023-A1 TRIAZINE-OXADIAZOLES NOVARTIS AG (CH) 2012-03-22 WO disclosed