Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434370 | 0.79 | SRD5A2 (0.54) | GRIA4PTGS2 | |
| SCHEMBL28005018 | 0.77 | TYR (0.50) | TYRGRIA4AKR1C3AKR1C2ALDH1A3 | |
| SCHEMBL1140292 | 0.75 | TYR (0.57) | TYRGRIA4AKR1C3AKR1C2PTGS2 | |
| SCHEMBL14127824 | 0.73 | KCNA5 (0.50) | PTGS2 | |
| SCHEMBL693837 | 0.73 | TYR (0.59) | TYRAKR1C3AKR1C2PTGS2 | |
| SCHEMBL11704768 | 0.73 | TYR (0.59) | TYRAKR1C3AKR1C2PTGS2 | |
| SCHEMBL29954993 | 0.73 | TYR (0.59) | TYRAKR1C3AKR1C2PTGS2 | |
| SCHEMBL8084456 | 0.73 | MMP1 (0.42) | TYRGRIA4MMP1MMP2MMP3 | |
| SCHEMBL3457617 | 0.73 | TYR (0.86) | TYRGRIA4AKR1C3AKR1C2MMP1 | |
| SCHEMBL8070499 | 0.71 | SRD5A2 (0.68) | DRD1ALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757982-B1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 2000-09-20 | — | — | EP | disclosed |
| US-5965763-A | Biphenyl compounds | HOECHST MARION ROUSSEL (FR) | 1999-10-12 | — | — | US | disclosed |
| US-5827887-A | 5-ALPHA REDUCTASE INHIBITORS | ROUSSEL UCLAF (FR) | 1998-10-27 | — | — | US | disclosed |
| EP-0757982-A1 | Biphenylic compounds, process for their preparations and intermediates for this process, their use as 5-alpha-reductase inhibitors and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-02-12 | — | — | EP | disclosed |