SCHEMBL8080150

SCHEMBL8080150

C[Si](C)(C)c1nc2nc(N)nc(Cl)c2[nH]1

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.44
ADORA2A P29274 3/20 0.35
ADORA1 P30542 3/20 0.35
NUDT1 P36639 1/20 0.35
PNP P00491 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3964705 0.81 PDPK1 (0.41) NUDT1
SCHEMBL6356987 0.80 PNP (0.54) DPP4ADORA2AADORA1NUDT1PNP
SCHEMBL6358281 0.77 NUDT1 (0.58) DPP4ADORA2AADORA1NUDT1PNP
SCHEMBL3158628 0.76 DPP4 (0.50) DPP4ADORA2AADORA1NUDT1PNP
SCHEMBL10597942 0.72 PNP (0.70) PNP
SCHEMBL11878666 0.70 EGLN1 (0.40) DPP4ADORA2AADORA1NUDT1
SCHEMBL6358729 0.69 DPP4 (0.43) DPP4L3MBTL1
SCHEMBL6363421 0.69 DPP4 (0.43) DPP4ADORA2AADORA1NUDT1
SCHEMBL9660056 0.68 PNP (0.31) ADORA2AADORA1PNP
SCHEMBL2098711 0.66 DPP4 (0.44) DPP4PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6034087-A VIRICIDE AGAINST HEPATITIS B CHONG KUN DANG CORP. (KR) 2000-03-07 US disclosed
EP-0869953-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF CHONG KUN DANG CORP (KR) 1998-10-14 EP disclosed
WO-1996012716-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF CHONG KUN DANG CORP. (KR) 1996-05-02 WO disclosed