SCHEMBL3964705

SCHEMBL3964705

C[Si](C)(C)c1nc2nc(N)nc(N)c2[nH]1

nearest known ligand 0.46

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 1/20 0.41
GDA Q9Y2T3 1/20 0.41
NUDT1 P36639 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9660056 0.82 PNP (0.31)
SCHEMBL8080150 0.81 DPP4 (0.44) NUDT1
SCHEMBL3396382 0.79 PNP (0.52) PDPK1GDA
SCHEMBL2634662 0.75 NUDT1 (0.61) PDPK1GDANUDT1
SCHEMBL1251786 0.72
SCHEMBL16513157 0.71 PDPK1 (0.44) PDPK1GDA
SCHEMBL5133438 0.71 ADORA2A (0.55) PDPK1GDANUDT1
SCHEMBL4907123 0.71 PDPK1 (0.44) PDPK1GDA
SCHEMBL29062538 0.71 PDPK1 (0.44) PDPK1GDA
SCHEMBL1705024 0.71 PDPK1 (0.44) PDPK1GDA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7560550-B2 Method for the production of OH protected[4-(2.6-diamino-9H-purine-9-yl)-1.3-dioxolane-2-yl]methanol derivatives RFS PHARMA, LLC (US) 2009-07-14 US disclosed
EP-1648894-B1 METHOD FOR THE PRODUCTION OF OH PROTECTED [4-(2.6-DIAMINO-9H-PURINE-9-YL)- 1.3-DIOXOLANE-2-YL]METHANOL DERIVATIVES WACKER CHEMIE AG (DE) 2007-09-12 EP disclosed
US-20060211855-A1 Method for the production of oh protected{4-(2.6-diamino-9h-purine-9-yl)-1.3-dioxolane-2-yl] methanol derivatives WACKER CHEMIE AG (DE) 2006-09-21 US disclosed
EP-1648894-A1 METHOD FOR THE PRODUCTION OF OH PROTECTED [4-(2.6-DIAMINO-9H-PURINE-9-YL)- 1.3-DIOXOLANE-2-YL]METHANOL DERIVATIVES Wacker Chemie AG (DE) 2006-04-26 EP disclosed
WO-2005012302-A1 METHOD FOR THE PRODUCTION OF OH PROTECTED [4-(2.6-DIAMINO-9H-PURINE-9-YL)- 1.3-DIOXOLANE-2-YL]METHANOL DERIVATIVES WACKER CHEMIE AG (DE) 2005-02-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211855-A1 Method for the production of oh protected{4-(2.6-diamino-9h-purine-9-yl)-1.3-dioxolane-2-yl] methanol derivatives FUT6, FUT5, ST6GAL1 PDPK1 2047/4885GDA 131/4885NUDT1 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.