Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 2/20 | 0.41 |
| ▸ | EDNRA | P25101 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951387 | 0.89 | ALOX5 (0.53) | ALOX5TOP2AEDNRBEDNRALMNA | |
| SCHEMBL8080333 | 0.86 | ALOX5 (0.47) | ALOX5EDNRBEDNRALMNAALDH1A1 | |
| SCHEMBL8086646 | 0.83 | ALOX5 (0.51) | ALOX5TOP2ALMNAKDM4EALDH1A1 | |
| SCHEMBL8081527 | 0.81 | ALOX5 (0.48) | ALOX5TOP2ALMNAALDH1A1HSD17B10 | |
| SCHEMBL8081502 | 0.80 | ALOX5 (0.55) | ALOX5KDM4EKMT2AMEN1CYP1A1 | |
| SCHEMBL8085115 | 0.80 | ALOX5 (0.53) | ALOX5TOP2ALMNAKDM4EALDH1A1 | |
| SCHEMBL2952410 | 0.78 | ALOX5 (0.71) | ALOX5LMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL8072504 | 0.76 | ALOX5 (0.56) | ALOX5KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL8084967 | 0.76 | ALOX5 (0.56) | ALOX5KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL8080571 | 0.76 | ALOX5 (0.62) | ALOX5TOP2AEDNRBLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |