Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 7/20 | 0.44 |
| ▸ | EDNRB | P24530 | 4/20 | 0.42 |
| ▸ | EDNRA | P25101 | 4/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081502 | 0.86 | ALOX5 (0.55) | ALOX5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8080340 | 0.86 | ALOX5 (0.45) | ALOX5EDNRBEDNRALMNAALDH1A1 | |
| SCHEMBL8081504 | 0.85 | MAOB (0.46) | ALOX5MAOBEDNRBEDNRAGSTP1 | |
| SCHEMBL8085115 | 0.84 | ALOX5 (0.53) | ALOX5AURKAKDRLMNANPC1 | |
| SCHEMBL8072504 | 0.82 | ALOX5 (0.56) | ALOX5AURKAALDH1A1HPGDSMN1; SMN2 | |
| Oxalic Acid SCHEMBL8086844 | 0.81 | ALOX5 (0.43) | ALOX5EDNRBEDNRALMNAALDH1A1 | |
| SCHEMBL8080562 | 0.80 | ALOX5 (0.56) | ALOX5NPSR1 | |
| SCHEMBL8084927 | 0.80 | ALOX5 (0.56) | ALOX5GRM5 | |
| SCHEMBL8084967 | 0.80 | ALOX5 (0.56) | ALOX5KDRNPC1ALDH1A1RAB9A | |
| SCHEMBL2952410 | 0.80 | ALOX5 (0.71) | ALOX5LMNANPC1ALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |