Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.69 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.69 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286757 | 0.83 | GABRA1 (0.71) | GABRA1GABRB1BCL2MCL1SMN1; SMN2 | |
| SCHEMBL2410206 | 0.82 | GABRA1 (0.70) | GABRA1GABRB1BCL2MCL1RAB9A | |
| SCHEMBL29405385 | 0.82 | GABRA1 (1.00) | GABRA1GABRB1BCL2MCL1RAB9A | |
| SCHEMBL13639493 | 0.81 | GABRA1 (0.69) | GABRA1GABRB1BCL2MCL1SMN1; SMN2 | |
| SCHEMBL8081937 | 0.81 | GABRA1 (0.69) | GABRA1GABRB1BCL2MCL1NPC1 | |
| SCHEMBL8077296 | 0.81 | GABRA1 (0.69) | GABRA1GABRB1BCL2MCL1LMNA | |
| SCHEMBL28078271 | 0.81 | GABRA1 (0.78) | GABRA1GABRB1BCL2MCL1LMNA | |
| SCHEMBL8081939 | 0.80 | GABRA1 (0.61) | GABRA1GABRB1BCL2MCL1LMNA | |
| SCHEMBL30153175 | 0.79 | PARP1 (0.68) | NPC1RAB9ASMN1; SMN2GAAHTT | |
| SCHEMBL241785 | 0.79 | PARP1 (0.68) | NPC1RAB9ASMN1; SMN2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7586008-B2 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7586008-B2 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-20080275100-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | ABRAXIS BIOSCIENCE, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080275100-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | ABRAXIS BIOSCIENCE, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20070185217-A1 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| US-20070185217-A1 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| WO-2005063665-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | ABRAXIS BIOSCIENCE, INC (US) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275100-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | CYP3A5, CYP3A4, GABARAP | GABRA1 32/4885GABRB1 81/4885BCL2 4801/4885 |
| US-20070185217-A1 | Propofol analogs, process for their preparation, and methods of use | CYP3A5, CYP3A4, GABARAP | GABRA1 32/4885GABRB1 81/4885BCL2 4801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.