Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.71 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.71 |
| ▸ | CNR2 | P34972 | 3/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405385 | 0.83 | GABRA1 (1.00) | GABRA1GABRB1BCL2MCL1GAA | |
| SCHEMBL8081937 | 0.83 | GABRA1 (0.69) | GABRA1GABRB1CNR2BCL2MCL1 | |
| SCHEMBL8080419 | 0.83 | GABRA1 (0.69) | GABRA1GABRB1BCL2MCL1GAA | |
| SCHEMBL13639493 | 0.83 | GABRA1 (0.69) | GABRA1GABRB1BCL2MCL1GAA | |
| SCHEMBL8077296 | 0.83 | GABRA1 (0.69) | GABRA1GABRB1BCL2MCL1GAA | |
| SCHEMBL28078271 | 0.82 | GABRA1 (0.78) | GABRA1GABRB1BCL2MCL1GAA | |
| SCHEMBL8077322 | 0.81 | GABRA1 (0.72) | GABRA1GABRB1CNR2BCL2MCL1 | |
| SCHEMBL186545 | 0.80 | PARP1 (0.68) | CNR2KCNK3KCNK9POLBPARP1 | |
| SCHEMBL29503529 | 0.80 | PARP1 (0.68) | CNR2KCNK3KCNK9POLBPARP1 | |
| SCHEMBL8077306 | 0.80 | GABRA1 (0.65) | GABRA1GABRB1CNR2BCL2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520290-B1 | Propofol analogs, process for their preparation, and methods of use | ABRAXIS BIOSCIENCE LLC (US) | 2014-12-10 | — | — | EP | disclosed |
| EP-2520290-A1 | Propofol analogs, process for their preparation, and methods of use | Abraxis BioScience, LLC (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2005063665-A1 | PROPOFOL ANALOGS, PROCESS FOR THEIR PREPARATION, AND METHODS OF USE | ABRAXIS BIOSCIENCE, INC (US) | 2005-07-14 | — | — | WO | disclosed |