Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.37 |
| ▸ | ACE known ✓ | P12821 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8081053 | 1.00 | DRD4 (0.39) | DRD4DRD2SLC6A5SLC6A2SLC6A3 | |
| Maleic Acid SCHEMBL11706279 | 0.77 | ALDH1A1 (0.58) | DRD4TDP1L3MBTL1LMNASMN1; SMN2 | |
| Fumaric Acid SCHEMBL11706290 | 0.77 | ALDH1A1 (0.58) | DRD4TDP1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL8800897 | 0.76 | ALDH1A1 (0.55) | DRD4DRD2LMNASMN1; SMN2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8092726 | 0.75 | KDM4E (0.56) | DRD4DRD2LMNASMN1; SMN2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8094716 | 0.73 | ACHE (0.47) | LMNAFEN1SIGMAR1KDM4EKMT2A | |
| SCHEMBL11559591 | 0.68 | CYP1A2 (0.51) | DRD4DRD2LMNASMN1; SMN2SIGMAR1 | |
| SCHEMBL11544067 | 0.68 | TSHR (0.40) | DRD4DRD2LMNASMN1; SMN2SIGMAR1 | |
| SCHEMBL1817425 | 0.67 | TDP1 (0.54) | DRD4TDP1L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL1817426 | 0.67 | TDP1 (0.54) | DRD4TDP1L3MBTL1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043368-A | Method of making thieno-pyridine derivatives | POLI INDUSTRIA CHIMICA, S.P.A. (IT) | 2000-03-28 | — | — | US | disclosed |
| EP-0829482-A2 | Method of making thieno-pyridine derivatives | Poli Industria Chimica S.p.A. (IT) | 1998-03-18 | — | — | EP | disclosed |