Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 9/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081260 | 0.86 | AGTR1 (0.37) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL8702070 | 0.83 | JAK2 (0.37) | AGTR1AGTR2 | |
| SCHEMBL9263754 | 0.81 | AGTR1 (0.44) | BDKRB1AGTR1AGTR2 | |
| SCHEMBL7575469 | 0.80 | BDKRB1 (0.44) | BDKRB1LTB4R2SOAT1AGTR1AGTR2 | |
| SCHEMBL4609709 | 0.80 | LTB4R2 (0.60) | BDKRB1LTB4R2 | |
| SCHEMBL9479331 | 0.79 | AGTR1 (0.44) | BDKRB1LTB4R2AGTR1AGTR2 | |
| SCHEMBL8088507 | 0.78 | JAK2 (0.35) | AGTR1AGTR2 | |
| SCHEMBL8953441 | 0.78 | BDKRB1 (0.38) | BDKRB1 | |
| SCHEMBL7570660 | 0.72 | PTGER1 (0.41) | BDKRB1SOAT1 | |
| SCHEMBL9709753 | 0.72 | LTB4R2 (0.42) | LTB4R2AGTR1AGTR2ABCB11GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |