Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL50429 | 0.83 | TSHR (0.53) | POLBHPGDALDH1A1CYP3A4KDM4E | |
| SCHEMBL8633486 | 0.79 | ALDH1A1 (0.62) | POLBHPGDMAPK1ALDH1A1KDM4E | |
| SCHEMBL13851903 | 0.79 | L3MBTL1 (0.55) | POLBIGFBP3HPGDMAPK1ALDH1A1 | |
| SCHEMBL8487061 | 0.78 | POLB (0.58) | POLBHPGDMAPK1ALDH1A1KDM4E | |
| SCHEMBL8633483 | 0.78 | IGFBP3 (0.50) | IGFBP3HPGDMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL28888875 | 0.76 | ALDH1A1 (0.50) | IGFBP3HPGDMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL258223 | 0.76 | ALDH1A1 (0.55) | POLBALDH1A1CYP3A4KDM4ELMNA | |
| SCHEMBL14974629 | 0.75 | TSHR (0.49) | POLBHPGDMAPK1ALDH1A1CYP1A2 | |
| SCHEMBL2129407 | 0.74 | SMN1; SMN2 (0.59) | HPGDALDH1A1CYP3A4KDM4ELMNA | |
| SCHEMBL15738996 | 0.74 | KMT2A (0.53) | ALDH1A1CYP1A2CYP3A4CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026935-A1 | CATECHOLAMINE DERIVATIVES AND PRODRUGS THEREOF | H. LUNDBECK A/S (DK) | 2009-03-05 | — | — | WO | disclosed |