Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5874071 | 0.89 | KEAP1 (0.46) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 | |
| SCHEMBL9048011 | 0.85 | LMNA (0.32) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 | |
| SCHEMBL8132915 | 0.84 | KEAP1 (0.41) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 | |
| SCHEMBL1444489 | 0.80 | KEAP1 (0.49) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 | |
| SCHEMBL6241091 | 0.80 | LMNA (0.63) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 | |
| SCHEMBL28331885 | 0.80 | KDM4E (0.52) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 | |
| SCHEMBL7489676 | 0.79 | ALDH1A1 (0.47) | LMNACYP2C9KDM4EALDH1A1MEN1 | |
| Fluoride SCHEMBL5144825 | 0.78 | LMNA (0.61) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 | |
| SCHEMBL22774208 | 0.77 | KEAP1 (0.46) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 | |
| SCHEMBL5144832 | 0.77 | LMNA (0.60) | KEAP1NFE2L2LMNACYP2C9ATP6V1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6018054-A | INTERMEDIATE COMPOUNDS FOR PREPARING NOVEL QUINOLONE AND NAPHTHYRIDONE DERIVATIVES WHICH ARE SUBSTITUTED IN THE 7-POSITION BY A PARTIALLY HYDROGENATED ISOINDOLINYL RING, USE AS ANTIBACTERIAL AGENTS AND AS FEED ADDITIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| CN-1044118-C | 7-isoindolinyl-quinolone derivatives and process for their preparation | BAYER AG (DE) | 1999-07-14 | — | — | CN | disclosed |
| CN-1189494-A | Substituted isoazalene compound | BAYER AG (DE) | 1998-08-05 | — | — | CN | disclosed |
| US-5739339-A | BACTERICIDES, ANTIPROTOZOA AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-04-14 | — | — | US | disclosed |
| US-5556979-A | ANIMAL FEEDS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-09-17 | — | — | US | disclosed |
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |