SCHEMBL8083350

SCHEMBL8083350

CCc1c(C(=O)O)c(=O)oc2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.53
CA9 Q16790 2/20 0.53
ALDH1A1 P00352 4/20 0.52
LMNA P02545 2/20 0.51
HTT P42858 1/20 0.51
NQO1 P15559 3/20 0.48
CYP2C9 P11712 2/20 0.47
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
ABCB11 O95342 1/20 0.47
TP53 P04637 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
TSHR P16473 1/20 0.47
MAPK1 P28482 1/20 0.47
CYP2C19 P33261 1/20 0.47
PDE4D Q08499 1/20 0.47
PCSK7 Q16549 1/20 0.47
GPR35 Q9HC97 1/20 0.47
KDM4E B2RXH2 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13506406 1.00 CA12 (0.53) CA12CA9ALDH1A1LMNAHTT
SCHEMBL28716052 0.86 BRAF (0.50) CA12CA9ALDH1A1LMNAHTT
SCHEMBL10710132 0.84 CA12 (0.49) CA12CA9ALDH1A1LMNAHTT
SCHEMBL13506405 0.82 ALDH1A1 (0.61) CA12CA9ALDH1A1LMNATSHR
SCHEMBL2226799 0.81 ESR2 (0.57) ALDH1A1LMNANQO1KMT2AMEN1
SCHEMBL10651637 0.81 SLC22A12 (0.50) ALDH1A1HTTNQO1CYP2C9KMT2A
SCHEMBL27212655 0.81 CA12 (0.46) CA12CA9ALDH1A1LMNAHTT
SCHEMBL1707603 0.80 NQO1 (0.56) ALDH1A1LMNANQO1CYP2C9KMT2A
SCHEMBL7753264 0.80 CA12 (0.57) CA12CA9ALDH1A1LMNAHTT
SCHEMBL11484411 0.80 NQO1 (0.52) ALDH1A1NQO1CYP2C9KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP claimed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US claimed
US-11044931-B2 Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof BASF SE (DE) 2021-06-29 US disclosed
EP-2758041-B1 LOW-MOLECULAR MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE OF SAME BASF SE (DE) 2021-01-13 EP disclosed
US-20190350239-A1 LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF BASF SE (DE) 2019-11-21 US disclosed
US-10398159-B2 Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof BASF SE (DE) 2019-09-03 US disclosed
US-20170265510-A1 LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF BASF SE (DE) 2017-09-21 US disclosed
EP-2758041-A1 LOW MOLECULAR WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE THEREOF BASF SE (DE) 2014-07-30 EP disclosed
US-20130251647-A1 LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF BASF SE (DE) 2013-09-26 US disclosed
WO-2013041621-A1 LOW MOLECULAR WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE THEREOF BASF SE (DE) 2013-03-28 WO disclosed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP disclosed
EP-0743573-B1 Method for obtaining image contrast migration imaging members XEROX CORP (US) 2000-09-06 EP disclosed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP disclosed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP disclosed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US disclosed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170265510-A1 LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF TRPM8, TRPM7, TRPM2 CA12 2349/4885CA9 2632/4885ALDH1A1 3977/4885
US-11044931-B2 Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof TRPM8, TRPM7, TRPM2 CA12 2349/4885CA9 2632/4885ALDH1A1 3977/4885
US-10398159-B2 Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof TRPM8, TRPM7, TRPM2 CA12 2349/4885CA9 2632/4885ALDH1A1 3977/4885
US-20130251647-A1 LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF TRPM8, TRPM7, TRPM2 CA12 2349/4885CA9 2632/4885ALDH1A1 3977/4885
US-20190350239-A1 LOW MOLECULAR WEIGHT MODULATORS OF THE COLD MENTHOL RECEPTOR TRPM8 AND USE THEREOF TRPM8, TRPM7, TRPM2 CA12 2349/4885CA9 2632/4885ALDH1A1 3977/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.