Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450471 | 0.81 | RORC (0.39) | RORCKMT2AMCL1BCL2L1 | |
| SCHEMBL5174385 | 0.81 | ALDH1A1 (0.45) | RORCKMT2AMCL1BCL2L1 | |
| SCHEMBL7609854 | 0.75 | RORC (0.39) | RORCKMT2AMCL1BCL2L1 | |
| SCHEMBL7343868 | 0.74 | RORC (0.47) | RORCMCL1BCL2L1 | |
| SCHEMBL2578313 | 0.73 | MCL1 (0.50) | RORCMCL1BCL2L1 | |
| SCHEMBL7451743 | 0.73 | RORC (0.45) | RORCMCL1TSHRBCL2L1 | |
| SCHEMBL7450627 | 0.72 | RORC (0.46) | RORCMCL1BCL2L1 | |
| SCHEMBL5031155 | 0.69 | RORC (0.40) | RORC | |
| SCHEMBL2576483 | 0.69 | SPPL2A (0.35) | RORC | |
| SCHEMBL7452491 | 0.68 | KEAP1 (0.50) | RORCMCL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43802-E1 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G.D. SEARLE LLC (US) | 2012-11-13 | — | — | US | claimed |
| US-6140505-A | REACTING A BENZO FUSED HETEROCYCLIC COMPOUND WITH AN SO3 COMPLEX IN THE PRESENCE OF A WATER IMMISCIBLE, NON-REACTIVE SOLVENT, AT A TEMPERATURE OF FROM ABOUT 0 TO ABOUT 75 DEGREES C., COOLING AND THEN ADDING OXALYL HALIDE. | G. D. SEARLE & CO. (US) | 2000-10-31 | — | — | US | disclosed |