Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084314 | 0.90 | RECQL (0.43) | KMT2AMAPTHTTLMNASMN1; SMN2 | |
| SCHEMBL8088718 | 0.87 | HIF1A (0.38) | KMT2AMAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8084404 | 0.87 | ABCC9 (0.35) | KMT2AMAPTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL8084939 | 0.86 | ABCC9 (0.35) | KMT2AMAPTHTTALDH1A1GAA | |
| SCHEMBL8088491 | 0.86 | ALDH1A1 (0.36) | KMT2AMAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8084968 | 0.84 | HTT (0.37) | KMT2AMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8084249 | 0.83 | HIF1A (0.35) | KMT2AMAPTALDH1A1MEN1L3MBTL1 | |
| SCHEMBL8088387 | 0.82 | ABCC9 (0.41) | LMNA | |
| SCHEMBL8090587 | 0.82 | CFTR (0.38) | MAPTSMN1; SMN2GAA | |
| SCHEMBL8088872 | 0.81 | ABCC9 (0.47) | KMT2AMAPTHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |