Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL11332262 | 0.92 | TSHR (0.31) | TSHRTDP1ALDH1A1 | |
| Lithium Ion SCHEMBL589 | 0.92 | TSHR (0.31) | TSHRTDP1ALDH1A1 | |
| Lithium Ion SCHEMBL11332267 | 0.92 | TSHR (0.31) | TSHRTDP1ALDH1A1 | |
| SCHEMBL107947 | 0.92 | ALDH1A1 (0.36) | TSHRTDP1ALDH1A1 | |
| Lithium Ion SCHEMBL14812375 | 0.89 | — | — | |
| Lithium Ion SCHEMBL2059893 | 0.89 | — | — | |
| Lithium Ion SCHEMBL9293254 | 0.89 | — | — | |
| Lithium Ion SCHEMBL9293243 | 0.89 | — | — | |
| SCHEMBL1939142 | 0.88 | ALDH1A1 (0.33) | TSHRTDP1ALDH1A1 | |
| SCHEMBL590 | 0.88 | ALDH1A1 (0.33) | TSHRTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1457482-B9 | Stable isotope-labeled amino acid, method of integrating the same into target protein, method of NMR structural analysis of protein | JAPAN SCIENCE & TECH AGENCY (JP) | 2012-10-24 | — | — | EP | disclosed |
| EP-1457482-B1 | Stable isotope-labeled amino acid, method of integrating the same into target protein, method of NMR structural analysis of protein | JAPAN SCIENCE & TECH AGENCY (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-7022310-B2 | Stable isotope-labeled amino acid and method for incorporating same into target protein | AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20050084452-A1 | Stable isotope-labeled amino acid and method for incorporating same into target protein | JAPANESE SCIENCE AND TECHNOLOGY AGENCY | 2005-04-21 | — | — | US | disclosed |
| EP-1457482-A1 | STABLE ISOTOPE-LABELED AMINO ACID, METHOD OF INTEGRATING THE SAME INTO TARGET PROTEIN, METHOD OF NMR STRUCTURAL ANALYSIS OF PROTEIN AND PROCESS FOR PRODUCING SITE-SELECTIVE STABLE ISOTOPE-LABELED FUMARIC ACID AND TARTARIC ACID | Japan Science and Technology Agency (JP) | 2004-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050084452-A1 | Stable isotope-labeled amino acid and method for incorporating same into target protein | GEMIN5, ATIC, AIP | TSHR 2848/4885TDP1 2575/4885ALDH1A1 4079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.