Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084566 | 0.94 | KMT2A (0.43) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8085467 | 0.89 | GRIK1 (0.48) | GRIK1PPARGPPARAKMT2ACYP2D6 | |
| SCHEMBL8085443 | 0.89 | GRIK1 (0.48) | GRIK1PPARGPPARAKMT2ACYP2D6 | |
| SCHEMBL8077436 | 0.89 | FAAH (0.47) | — | |
| SCHEMBL8084679 | 0.84 | TRPA1 (0.48) | — | |
| SCHEMBL16156176 | 0.81 | KMT2A (0.48) | KMT2ACYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL16149006 | 0.81 | KMT2A (0.48) | KMT2ACYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL6190476 | 0.81 | KMT2A (0.48) | KMT2ACYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL28014450 | 0.81 | GRIK1 (0.57) | GRIK1PPARGPPARAKMT2ACYP2D6 | |
| SCHEMBL11206513 | 0.80 | CYP2D6 (0.49) | GRIK1KMT2ACYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835240-B1 | MATRIX METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-5917090-A | INHIBIT TUMOR NECROSIS FACTOR; ANTIARTHRITIC AGENTS | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 1999-06-29 | — | — | US | disclosed |
| EP-0835240-A1 | MATRIX METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997002239-A1 | MATRIX METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-01-23 | — | — | WO | disclosed |