Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085443 | 0.94 | GRIK1 (0.48) | MAPTRXFP1 | |
| SCHEMBL8085467 | 0.94 | GRIK1 (0.48) | MAPTRXFP1 | |
| SCHEMBL8077436 | 0.84 | FAAH (0.47) | TRPA1MAPTRXFP1FAAHALOX5 | |
| SCHEMBL8084641 | 0.84 | GRIK1 (0.44) | — | |
| SCHEMBL8085479 | 0.83 | FAAH (0.42) | TRPA1FAAHS1PR2S1PR4S1PR1 | |
| SCHEMBL7319532 | 0.83 | MAPT (0.51) | TRPA1MAPTRXFP1LTB4RS1PR2 | |
| SCHEMBL5514990 | 0.81 | PPARG (0.54) | TRPA1MAPTRXFP1FAAHLTB4R | |
| SCHEMBL29015070 | 0.79 | TRPA1 (0.51) | TRPA1MAPTRXFP1FAAHLTB4R | |
| SCHEMBL28014450 | 0.78 | GRIK1 (0.57) | TRPA1MAPTRXFP1 | |
| SCHEMBL8084566 | 0.78 | KMT2A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835240-B1 | MATRIX METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-5917090-A | INHIBIT TUMOR NECROSIS FACTOR; ANTIARTHRITIC AGENTS | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 1999-06-29 | — | — | US | disclosed |
| EP-0835240-A1 | MATRIX METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997002239-A1 | MATRIX METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-01-23 | — | — | WO | disclosed |