Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088445 | 0.89 | ADORA3 (0.41) | RECQLTDP1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL8088352 | 0.86 | KDM4E (0.37) | RECQLTDP1HSP90AA1KDM4EHTT | |
| SCHEMBL10697020 | 0.85 | ALDH1A1 (0.36) | RECQLTDP1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8084289 | 0.83 | CFTR (0.41) | RECQLTDP1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL8090699 | 0.83 | ALDH1A1 (0.37) | POLBTDP1KDM4EHTTALDH1A1 | |
| SCHEMBL8085305 | 0.83 | ALDH1A1 (0.36) | TDP1HTTALDH1A1MALT1CA9 | |
| SCHEMBL8077039 | 0.83 | ALDH1A1 (0.36) | TDP1HTTALDH1A1MALT1CA9 | |
| SCHEMBL7274143 | 0.82 | PDE4A (0.42) | KDM4EADORA3ADORA2ATYMSMALT1 | |
| SCHEMBL8088675 | 0.82 | RECQL (0.44) | RECQLPOLBTDP1HSP90AA1CCR6 | |
| SCHEMBL7292380 | 0.80 | CCNC (0.32) | KDM4EADORA3ADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |