Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697020 | 0.86 | ALDH1A1 (0.36) | ALDH1A1CYP3A4TDP1CA9RECQL | |
| SCHEMBL8085141 | 0.86 | RECQL (0.44) | KDM4EHSP90AA1ALDH1A1MAPTTDP1 | |
| SCHEMBL8090699 | 0.85 | ALDH1A1 (0.37) | KDM4EALDH1A1MAPTCYP3A4TDP1 | |
| SCHEMBL8077039 | 0.84 | ALDH1A1 (0.36) | ALDH1A1CYP3A4TDP1CA9HTT | |
| SCHEMBL8085305 | 0.84 | ALDH1A1 (0.36) | ALDH1A1CYP3A4TDP1CA9HTT | |
| SCHEMBL8084289 | 0.83 | CFTR (0.41) | KDM4EMAPTTDP1RECQLHTT | |
| SCHEMBL8088445 | 0.82 | ADORA3 (0.41) | KDM4EALDH1A1MAPTCYP3A4TDP1 | |
| SCHEMBL8077021 | 0.82 | PDE4A (0.40) | KDM4E | |
| SCHEMBL8090492 | 0.81 | KDM4E (0.36) | KDM4EHSP90AA1ALDH1A1MAPTMAOA | |
| SCHEMBL7268307 | 0.81 | ALDH1A1 (0.39) | ALDH1A1MAPTCYP3A4TDP1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |