Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 10/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.31 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076916 | 0.90 | ABCC9 (0.38) | ABCC9MALT1MIFABCB1 | |
| SCHEMBL8088721 | 0.88 | MALT1 (0.33) | ABCC9MALT1PDE4APDE4BPDE4C | |
| SCHEMBL8090107 | 0.86 | ABCC9 (0.35) | ABCC9MALT1MIFPDE4APDE4B | |
| SCHEMBL8084273 | 0.84 | VCAM1 (0.38) | ABCC9MALT1MIF | |
| SCHEMBL8077233 | 0.84 | ABCC9 (0.40) | ABCC9MALT1MIFABCB1 | |
| SCHEMBL7268194 | 0.83 | ABCC9 (0.36) | ABCC9MALT1BACE1PDE4APDE4B | |
| SCHEMBL8084526 | 0.83 | ABCC9 (0.36) | ABCC9 | |
| SCHEMBL8088643 | 0.82 | CYP3A4 (0.36) | MALT1MIF | |
| SCHEMBL8090263 | 0.82 | MALT1 (0.33) | ABCC9MALT1PDE4APDE4BPDE4C | |
| SCHEMBL8077016 | 0.80 | PDE4A (0.42) | ABCC9MALT1BACE1MIFPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |