Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 12/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | DRD3 | P35462 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084925 | 0.89 | EGLN2 (0.33) | ABCC9EGLN2DRD2DRD3KDM4E | |
| SCHEMBL8085132 | 0.85 | EGLN2 (0.39) | ABCC9EGLN2DRD2DRD3KDM4E | |
| SCHEMBL8085335 | 0.85 | ABCC9 (0.35) | ABCC9EGLN2DRD2DRD3KDM4E | |
| SCHEMBL8076916 | 0.85 | ABCC9 (0.38) | ABCC9 | |
| SCHEMBL8084420 | 0.84 | CFTR (0.38) | — | |
| SCHEMBL8085360 | 0.83 | ABCC9 (0.37) | ABCC9 | |
| SCHEMBL8088696 | 0.83 | PDE4A (0.37) | ABCC9EGLN2DRD2DRD3KDM4E | |
| SCHEMBL8077023 | 0.82 | EGLN2 (0.36) | ABCC9EGLN2DRD2DRD3KDM4E | |
| SCHEMBL9375898 | 0.82 | ABCC9 (0.37) | ABCC9EGLN2DRD2DRD3KDM4E | |
| SCHEMBL7276803 | 0.81 | DRD2 (0.37) | ABCC9EGLN2DRD2DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |