Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | WRN | Q14191 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072870 | 0.93 | ALOX5 (0.55) | ALOX5KDRROCK2GSTP1NQO2 | |
| SCHEMBL8085101 | 0.89 | ALOX5 (0.52) | ALOX5KDRROCK2MAOBGSTP1 | |
| SCHEMBL8082235 | 0.88 | ALOX5 (0.48) | ALOX5GRM2KDRROCK2MAOB | |
| SCHEMBL8086679 | 0.88 | ALOX5 (0.48) | ALOX5GRM2KDRROCK2GSTP1 | |
| SCHEMBL8084959 | 0.84 | ALOX5 (0.47) | ALOX5KDRROCK2GSTP1NQO2 | |
| SCHEMBL8081908 | 0.84 | ALOX5 (0.49) | ALOX5ROCK2KMT2AHSD17B10NQO2 | |
| SCHEMBL8086655 | 0.84 | ROCK2 (0.49) | ALOX5KDRROCK2MAOBKMT2A | |
| SCHEMBL8086689 | 0.81 | ALOX5 (0.74) | ALOX5KMT2A | |
| SCHEMBL8080761 | 0.81 | ALOX5 (0.48) | ALOX5ROCK2POLBPTPN7MAPKAPK2 | |
| SCHEMBL8467392 | 0.81 | RXFP1 (0.52) | ALOX5KDRROCK2POLBMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |