Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8078829 | 0.77 | ALDH1A1 (0.36) | TSHRLMNAFGFR1FGFR2FGFR4 | |
| SCHEMBL3222329 | 0.76 | BCAT2 (0.38) | TSHRFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL6650153 | 0.70 | NPC1 (0.38) | TSHRSLC6A3SLC6A4FGFR1FGFR2 | |
| SCHEMBL9363066 | 0.68 | TSHR (0.47) | TSHRSLC6A3SLC6A4LMNAFGFR1 | |
| SCHEMBL4786063 | 0.67 | MAPT (0.51) | TSHRLMNAFGFR1SRCFGFR2 | |
| SCHEMBL69464 | 0.66 | SLC6A3 (0.67) | TSHRSLC6A3SLC6A4LMNAALDH1A1 | |
| SCHEMBL15514574 | 0.66 | CDC25B (0.55) | LMNAFGFR1SRCFGFR2FGFR4 | |
| SCHEMBL27358025 | 0.66 | FGFR1 (0.46) | TSHRLMNAFGFR1SRCFGFR2 | |
| SCHEMBL31315022 | 0.66 | CDC25B (0.55) | LMNAFGFR1SRCFGFR2FGFR4 | |
| Dimethyl Phthalate SCHEMBL27335020 | 0.65 | TSHR (0.71) | TSHRSLC6A3SLC6A4LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |