Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8086896 | 0.70 | TSHR (0.42) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL1070351 | 0.65 | CA12 (0.61) | RAB9ATSHRCA1CA2CA7 | |
| SCHEMBL18259555 | 0.65 | MAPT (0.52) | NPC1RAB9ASLC6A4SLC6A3MAPT | |
| SCHEMBL5775105 | 0.64 | ALDH1A1 (0.59) | TSHRHPGDMAPK1MAPTKMT2A | |
| SCHEMBL29600613 | 0.64 | MAOA (0.57) | — | |
| SCHEMBL3375220 | 0.63 | CA2 (0.46) | NPC1RAB9ACA1CA2CA7 | |
| SCHEMBL26632152 | 0.63 | SLC6A4 (0.45) | NPC1RAB9ATSHRHPGDCA1 | |
| SCHEMBL13824070 | 0.63 | SLC6A3 (0.53) | NPC1RAB9ATSHRHPGDSLC6A4 | |
| SCHEMBL1586686 | 0.63 | BDKRB1 (0.53) | NPC1RAB9ACA1CA2CA7 | |
| SCHEMBL26632162 | 0.63 | SLC6A3 (0.49) | NPC1RAB9ATSHRHPGDSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478624-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003068743-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-21 | — | — | WO | disclosed |