SCHEMBL8087484

SCHEMBL8087484

Cc1cn(C2COC(CO)CO2)c(=O)[nH]c1=O

nearest known ligand 0.64

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.53
ALB P02768 2/20 0.53
BLM P54132 2/20 0.53
ALDH1A1 P00352 1/20 0.53
POLB P06746 1/20 0.53
ADRA1A P35348 1/20 0.53
TK1 P04183 5/20 0.53
TSHR P16473 2/20 0.51
PKM P14618 1/20 0.51
PMP22 Q01453 1/20 0.51
CYP2D6 P10635 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8087489 0.85 LMNA (0.57) LMNAADRA1ATK1TSHRPMP22
SCHEMBL8091533 0.85 TK1 (0.57) LMNABLMADRA1ATK1TSHR
SCHEMBL8159691 0.85 SMN1; SMN2 (0.54) LMNABLMALDH1A1POLBTK1
SCHEMBL7701755 0.83 LMNA (0.55) LMNAALBBLMALDH1A1POLB
SCHEMBL6760136 0.83 LMNA (0.55) LMNAALBBLMALDH1A1POLB
SCHEMBL1130181 0.83 LMNA (0.55) LMNAALBBLMALDH1A1POLB
SCHEMBL1129572 0.83 LMNA (0.55) LMNAALBBLMALDH1A1POLB
SCHEMBL1129570 0.83 LMNA (0.55) LMNAALBBLMALDH1A1POLB
SCHEMBL6314490 0.83 LMNA (0.55) LMNAALBBLMALDH1A1POLB
SCHEMBL18837842 0.82 TK1 (0.66) LMNAALBBLMTK1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-3047045-B2 2000-05-29 JP claimed
EP-0869953-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF CHONG KUN DANG CORP (KR) 1998-10-14 EP claimed
WO-1996012716-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF CHONG KUN DANG CORP. (KR) 1996-05-02 WO claimed
US-6034087-A VIRICIDE AGAINST HEPATITIS B CHONG KUN DANG CORP. (KR) 2000-03-07 US disclosed
EP-0869953-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF CHONG KUN DANG CORP (KR) 1998-10-14 EP disclosed
WO-1996012716-A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR PREPARING THEREOF CHONG KUN DANG CORP. (KR) 1996-05-02 WO disclosed